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March 1974

Methotrexate Dosage Schedule

Author Affiliations

San Francisco

Arch Dermatol. 1974;109(3):407. doi:10.1001/archderm.1974.01630030061017

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To the Editor.—  I wish to point out a source of error in the cooperative study titled "Psoriasis-Liver-Methotrexate Interactions" appearing in the Archives (108:36, 1973). I have been puzzled for some time now by the statement of the International Cooperative Committee on this subject to the effect that the daily oral dosage schedule of methotrexate was found to be significantly associated with the presence of liver damage, with the implication that the weekly schedule and the Weinstein schedule were less offensive. This has not been the experience that a group at the University of California at San Francisco has recently shown in an article submitted to the Archives for publication.Some clarification of the problem is made in a separate article by one of the leaders of the aforementioned cooperative study.The statement is made in the article by Weinstein (Dermatol Digest 12:49, 1973) that the daily oral schedule referred

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