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April 1974

Acanthosis Nigricans Following Diethylstilbestrol TherapyOccurrence in Patients With Childhood Muscular Dystrophy

Author Affiliations


From the sections of dermatology and cardiology, Department of Medicine, the University of Chicago Pritzker School of Medicine, Chicago.

Arch Dermatol. 1974;109(4):545-546. doi:10.1001/archderm.1974.01630040051013

Acanthosis nigricans developed in two brothers with childhood (Duchenne) muscular dystrophy who were among six patients receiving diethylstilbestrol as an experimental treatment of their muscle disease. These observations and others suggest that estrogen may play some role in the development of this relatively uncommon skin disorder.