Acanthosis nigricans developed in two brothers with childhood (Duchenne) muscular dystrophy who were among six patients receiving diethylstilbestrol as an experimental treatment of their muscle disease. These observations and others suggest that estrogen may play some role in the development of this relatively uncommon skin disorder.
Banuchi SR, Cohen L, Lorincz AL, Morgan J. Acanthosis Nigricans Following Diethylstilbestrol TherapyOccurrence in Patients With Childhood Muscular Dystrophy. Arch Dermatol. 1974;109(4):545-546. doi:10.1001/archderm.1974.01630040051013