A young, adult woman with acne, accompanied by premenstrual flare-ups, developed the sudden onset of ovarian failure. Menopausal symptoms ensued, but the severity of the acne did not change appreciably; however, the cyclical exacerbation of the acne was abolished. Replacement gonadal hormone therapy with diethylstilbestrol and the progesterone derivative, medroxyprogesterone acetate, induced a reestablishment of the regular periodic flare-ups of the acne. These did not occur when estrogen alone was used. The observations in this patient suggest that the premenstrual flare-up of acne is most likely a progestational effect, but that the occurrence of acne is not dependent on functioning ovaries.
Pochi PE. Acne in Premature Ovarian FailureReestablishment of Cyclic Flare-Ups With Medroxyprogesterone Acetate Therapy. Arch Dermatol. 1974;109(4):556-557. doi:10.1001/archderm.1974.01630040062017