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April 1974

Tretinoin Therapy for Monilethrix

Author Affiliations

San Salvador, El Salvador

Arch Dermatol. 1974;109(4):575-576. doi:10.1001/archderm.1974.01630040079034

To the Editor.—  Monilethrix is a dysplasia of the hair shaft; it is characterized by eliptical nodes separated by constricted internodes at which the medulla is lacking. The disease is uncommon; its mechanism of production is unknown; and up until the present, to our knowledge, no effective treatment had been known.In the last few years, tretinoin has become a common therapeutic modality. Its effectiveness has been proved in the treatment of a variety of different conditions such as acne comedonicus,1 pseudoacanthosis nigricans,2 Darier disease,3 nevus comedonicus,4 senile comedones,5 trichostasis spinulosa,6 steroid-induced acne7 and in several kinds of icthiosis.8 Other conditions for which tretinoin therapy has been used include psoriasis,9 lichen planus,10 and keratodermia11; the effectiveness of tretinoin therapy in these cases must still be determined.Recently, we saw a patient with monilethrix, and we would like to report

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