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Case for Diagnosis: Mycosis Fungoides. Presented by Donald R. Shasky, MD.
A 35-year-old man has had an asymptomatic, spreading eruption on the trunk and extremities since 1968. The lesions, which are circular and measure as large as 5 to 6 cm, have erythematous, slightly elevated, scaly borders and poikilodermic centers. The patient has never had any treatment. Biopsy specimens have been taken from both the centers and borders of the lesions. Results of a complete blood count were within normal limits. A potassium hydroxide mount was negative.
Dr. Bernard Gottlieb: There is a polymorphous inflammatory process in which histiocytes, mononuclear cells, plasma cells, and eosinophiles participate; and there is an accumulation of these cells in the papillary dermis, with exocytosis of large histiocytes and mononuclear cells into the epidermis. There are substantial numbers of mitotic figures and large histiocytes that have indented nuclei. The changes are suggestive of mycosis
Gethner P. THE METROPOLITAN DERMATOLOGICAL SOCIETY OF LOS ANGELES. Arch Dermatol. 1974;109(4):585. doi:10.1001/archderm.1974.01630040085042