Latent Porphyria Cutanea Tarda: Retreatment With Chloroquine. Presented by C. Russell Anderson, MD.
A 67-year-old white man first had cutaneous signs of porphyria in 1958. In 1959, fragility of the skin, blistering, darkening of the facial skin, and periorbital hypertrichosis were noted. The patient's urine fluoresced a brilliant pink under Wood light. No alcoholic beverages were consumed since 1959. In October 1968, phlebotomy was initiated. At that time, the hemoglobin value was 17.3 gm/100 ml, and uroporphyrin excretion was 4,062μg in 24 hours. Five hundred milliliters of blood was removed every two weeks until 5 liters of blood had been taken. After the fifth phlebotomy, an acute exacerbation of the cutaneous findings occurred, associated with marked increased urinary fluorescence, and the 24-hour urinary excretion of uroporphyrins rose to 6,208μg. After the ninth phlebotomy, the clinical and chemical manifestations of porphyria had disappeared. At the tenth phlebotomy, the hemoglobin value was
Underwood LJ. THE LOS ANGELES DERMATOLOGICAL SOCIETY. Arch Dermatol. 1974;109(4):585-587. doi:10.1001/archderm.1974.01630040085043