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June 1974

2,4-Dinitrochlorobenzene Therapy for Plantar Warts

Author Affiliations


Presidio of San Francisco

Arch Dermatol. 1974;109(6):910. doi:10.1001/archderm.1974.01630060078024

To the Editor.—  Dr. Henry Lewis suggested the use of 2,4-dinitrochlorobenzene (DNCB) as therapy for plantar warts at the American Academy of Dermatology meeting in December 1972. Further efficacy of this therapy was reported by Greenberg et al in 1973.1 We suggested the therapy was working immunologically to enable the body to recognize the foreign virus. This therapy may find wide acceptance because of an abstract in Family Circle2 and a recent article by Dr. Lewis,3 who proposes large-scale exploration of this therapy.There are possible drawbacks to this treatment. According to H. Maibach, MD (oral communication, December 1973), autoeczematization is not rare. Fisher states: it has been shown that 40% of chloramphenicol sensitive subjects also reacted to 1-2-4 chlorodinitrobenzene. This makes it likely that human beings deliberately sensitized to chlorodinitrobenzene would react to chloramphenicol if this drug were administered systematically.4In his most recent edition,

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