Sixty-eight patients with a clinical diagnosis of cutaneous candidiasis confirmed by a potassium hydroxide (KOH) examination and culture studies were treated with haloprogin cream or nystatin ointment in a double-blind study. Each of the drugs was applied for 13 consecutive days. The results of clinical observations, KOH examination, and culture studies showed that there was no significant difference in the efficacy of these two drugs in the treatment of cutaneous candidal infections. The cure rate for both products exceeded 80%. The efficacy of haloprogin in the treatment of dermatophytoses and candidiasis shows that it has a broad spectrum of antimicrobial activity, with no known toxicity or reported important adverse reactions when used in the approved dosages.
Carter VH, Olansky S. Haloprogin and Nystatin Therapy for Cutaneous CandidiasisComparison of the Efficacy of Haloprogin and Nystatin Therapy. Arch Dermatol. 1974;110(1):81-82. doi:10.1001/archderm.1974.01630070049010