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August 1974

Glutaraldehyde Therapy for Epidermolysis Bullosa

Author Affiliations

Fontana, Calif

Arch Dermatol. 1974;110(2):297-298. doi:10.1001/archderm.1974.01630080085035

To the Editor.—  In the Archives (109:70, 1974), Drs. DesGroseilliers and Brisson report on glutaraldehyde treatment of localized epidermolysis bullosa, or recurrent bullous eruption of the hands and feet (RBEHF). Their conclusions indicate three general shortcomings, though they note the beneficial effects of 10% buffered glutaraldehyde. I have reported the use of glutaraldehyde in hyperhidrosis1 and in herpes zoster and simplex2 and its theoretical benefits in the treatment of Pseudomonas infection.3 This, together with its use in verruca vulgaris, plantar and genital warts, and tinea, has given me considerable experience that suggests that glutaraldehyde as reported by DesGroseilliers and Brisson may be useful in epidermolysis bullosa with the following technique.The starting strength of buffered glutaraldehyde should be 2% for nightly use. Within one week, there should be adequate control, when it may be used every other night. If glutaraldehye is still effective at this schedule,

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