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Vitamin E Treatment in a Case of Epidermolysis Bullosa. Presented by Gundula Schaumburg-Lever, MD, Walter F. Lever, MD.
A 25-year-old woman has had a blistering disease since birth. She spent the first six months of life in a hospital receiving massive doses of vitamin C and antibiotics. Beginning at age 11, she was treated intermittently with systemically administered corticosteroids. This was continued until 1971. In 1971, methotrexate therapy was begun, whereupon she underwent a remarkable remission. However, the methotrexate had to be discontinued after several months because of nausea. For the past four months, she has received 1,600 international units of vitamin E (Aquasol E) daily. There is no family history of a bullous disease.Examination of the skin revealed numerous bullae and denuded areas over the entire body. Fingernails were present only on the thumbs and right ring finger. Discrete scars were distributed over the entire body. Fingernails were
Hadley TP. NEW ENGLAND DERMATOLOGY SOCIETY. Arch Dermatol. 1974;110(2):308-309. doi:10.1001/archderm.1974.01630080092050