A 3-year-old boy had three episodes of erythema nodosum-like lesions that were initially thought to be associated with a granulomatous process. They were later found to be due to acute granulocytic leukemia, with histologic evidence of leukemic cells in the cutaneous lesions.
Sumaya CV, Babu S, Reed RJ. Erythema Nodosum-like Lesions of Leukemia. Arch Dermatol. 1974;110(3):415-418. doi:10.1001/archderm.1974.01630090053010