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September 1974

Contact Dermatitis to Substituted Imidazolidinyl Urea—A Common Preservative in Cosmetics

Author Affiliations

Miami, Fla

Arch Dermatol. 1974;110(3):463. doi:10.1001/archderm.1974.01630090089028

To the Editor.—  There have been no previous reports of allergic contact sensitivity to imidazolidinyl urea (Germall 115), which is a preservative that has found increasing popularity in the cosmetic industry.1 This is the report of a patient who had an acute contact dermatitis following the use of a popular moisturizing lotion containing Germall 115.

Report of a Case.—  A 49-year-old white woman had an acute eczematous dermatitis of the face of one week's duration. Her symptoms began two weeks after the daily use of an allergy-tested moisturizing lotion concentrate. The condition cleared up during a one-week period of therapy with a fluorinated steroid solution applied three times daily and abstinence from all cosmetics. Patch tests one week later to routine allergens, and a cosmetic kit (supplied by Texas Pharmacal Company, San Antonio) were negative except for a 2+ reaction to the offending moisturizer and to a hypoallergenic liquid

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