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To the Editor.—
A 22-year-old man with severe cystic acne has been treated for several years with tetracycline. In October 1973, he was placed on a regimen of demeclocycline hydrochloride (Declomycin), 300 mg, twice daily. He was given this drug for a total of four months, the dose ranging from 300 to 600 mg daily. He complained of diminished sex drive that initially was not taken seriously, and the drug was continued. A long discussion with the patient's wife verified the seriousness of the complaint; therefore, the demeclocycline was immediately stopped. His symptoms disappeared in one week after the drug was discontinued.Of course, one should consider a number of other possible causes for this patient's complaint. Still, we think it worth reporting on this single case in order to find out whether similar problems have been seen by any other dermatologist using demeclocycline in the management of acne.
Biro L, Price E. Demeclocycline Hydrochloride and Diminished Sex Drive. Arch Dermatol. 1974;110(4):637. doi:10.1001/archderm.1974.01630100085029