Two women had panniculitis caused by self-injection of drugs. One dissolved meperidine hydrochloride tablets in water and injected the solution into her thighs. The other did not admit self-inoculation, but roentgenograms of the nodules gave evidence of multiple calcifications. In both cases, biopsy specimens from the nodules showed multiple birefringent particles in polarized light.
Förström L, Winkelmann RK. Factitial Panniculitis. Arch Dermatol. 1974;110(5):747-750. doi:10.1001/archderm.1974.01630110041009