An 87-year-old woman had xanthoma disseminatum. Laboratory studies showed underlying multiple myeloma. This association may be coincidental, but it parallels the well-known relationship of generalized plane xanthoma with myelomatosis. As occurs in the latter case, this patient's myeloma appears to be following a benign course.
Maize JC, Ahmed AR, Provost TT. Xanthoma Disseminatum and Multiple Myeloma. Arch Dermatol. 1974;110(5):758-761. doi:10.1001/archderm.1974.01630110052014