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November 1974

Aminocaproic Acid in the Treatment of Exfoliative Dermatitis

Author Affiliations

Timonium, Md

Arch Dermatol. 1974;110(5):808. doi:10.1001/archderm.1974.01630110086030

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To the Editor.—  Aminocaproic acid (EACA), a six carbon aliphatic carboxylic acid with a terminal amino group, has been reported to be effective in the treatment of eczema and other allergic diseases of the skin by Yokoyama and Hatano (Keio Med J 8:303, 1959). The drug has also been shown by Miller to modify the skin response to purified protein derivative of tuberculin and streptokinase-streptodornase (Exp Med Surg 29:132, 1971). Opportunity to treat a patient with severe exfoliative dermatitis, resistant to many other forms of therapy, offered a challenge to treatment with EACA.

Report of a Case.—  A 54-year-old white man was admitted to the hospital with a generalized exfoliative dermatitis of ten weeks duration. An erythematous, thickened skin covered the entire body. Fissures were found over the distal parts of all extremities (Fig 1). The nails were soft and spoon-shaped.Treatment, in rotation and combination, with antihistaminic drugs, corticosteroids,

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