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To the Editor.—
What every dermatologist knows, as an article of faith, is that the little yellowish macules on the buccal mucosa or on the vermilion borders of the lips—Fordyce spots— are ectopic sebaceous glands. Histologic studies convinced Fordyce himself of this.Fordyce spots and comedones on the lip. Direct evidence of this is rare. However, the accompanying Figure provides it, to a degree. It is seen as a doughnut-shaped nodule of sebaceous hyperplasia on one side of a young man's upper vermilion; three comedones are on the other side. The usual macular lesions of the anomaly are easily seen between them.
Arnold HL. Fordyce Spots. Arch Dermatol. 1974;110(5):811. doi:10.1001/archderm.1974.01630110089035