Four of ten patients with pemphigus foliaceus were found to have antibodies reacting specifically with antigens present only in the subcorneal (SC) intercellular substance of the epidermis. Similar SC intercellular antibodies were found in only one of 709 control patients, including 73 patients with other forms of pemphigus, 68 with other bullous diseases, and 569 with miscellaneous dermatoses. These antibodies were distinct from those normally found in pemphigus vulgaris that react with intercellular antigens all layers of the epidermis. The anatomical location of the antigens reacting with SC intercellular antibodies corresponds to that of the earliest lesion seen in pemphigus foliaceus, and suggests that this form of pemphigus may be associated with distinctive antibodies.
Bystryn J, Abel E, DeFeo C. Pemphigus FoliaceusSubcorneal Intercellular Antibodies of Unique Specificity. Arch Dermatol. 1974;110(6):857-861. doi:10.1001/archderm.1974.01630120007001