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December 1974

Multiple Sebaceous Gland Tumors and Visceral Carcinomas

Author Affiliations

From the Moses H. Cone Memorial Hospital, Greensboro, NC, and the departments of pathology and dermatology, University of North Carolina School of Medicine, Chapel Hill, NC (Dr. Leonard). Dr. Deaton is in the private practice of surgery in Greensboro, NC.

Arch Dermatol. 1974;110(6):917-920. doi:10.1001/archderm.1974.01630120063015

The combination of multiple cutaneous sebaceous neoplasms and multiple visceral carcinomas represents a recently described syndrome. We have studied the case of a patient with malignant neoplasms of the colon, larynx, and uterus associated with seven sebaceous skin tumors and summarize the pertinent data on this case and nine previously reported cases. The internal cancers tend to arise in the gastrointestinal tract, particularly the colon, and apparently are of a low grade of malignancy. The multiple sebaceous tumors most often involve the trunk and usually develop after the visceral carcinoma is diagnosed. Epidermal skin tumors are also a feature of the syndrome.