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January 1975

A New Formula for Depigmenting Human Skin

Author Affiliations

From the Department of Dermatology, University of Pennsylvania, School of Medicine, Philadelphia.

Arch Dermatol. 1975;111(1):40-48. doi:10.1001/archderm.1975.01630130042004

Complete depigmentation of the normal skin of adult male blacks was procured by the daily application for five to seven weeks of a formula consisting of 0.1% tretinoin, 5.0% hydroquinone, 0.1% dexamethasone, and hydrophilic ointment. Depigmentation was not attainable when any one of the components was omitted.

The formula was therapeutically effective in treatment of melasma, ephelides, and postinflammatory hyperpigmentation. Senile lentigines were resistant to this therapy.