In a case of giant keratoacanthoma of the nose, the lesion was extremely invasive, destroying the entire nose. Electrosurgical removal of the grossly abnormal tissue was followed by rapid recurrence on two occasions. Radiation therapy was not effective. The lesion healed after the use of bleomycin sulfate.
Rapaport J. Giant Keratoacanthoma of the Nose. Arch Dermatol. 1975;111(1):73-75. doi:10.1001/archderm.1975.01630130075008