Because of the rarity of Darier's disease (keratosis follicularis) occurring as an acute, eruptive disease in a mature adult, a case with sudden onset in a 51-year-old white man is reported. Small, pale-gray, smooth papules on the sides of the arms spread to the sides of the chest, abdomen, and legs within a week. With a biopsy examination, histopathologic findings were acanthosis, hyperkeratosis, lacunae, acantholysis, corps ronds, and grains. Topical therapy with 0.05% fluocinonide (Lidex) cream has given marked improvement.
Fishman HC. Acute, Eruptive Darier Disease (Keratosis Follicularis)Occurrence in an Adult. Arch Dermatol. 1975;111(2):221-222. doi:10.1001/archderm.1975.01630140079009