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March 1975

Disodium Etidronate Therapy for Dystrophic Cutaneous Calcification

Author Affiliations

From the Department of Dermatology (Dr. Rabens) and Department of Medicine (Dr. Bethune), Los Angeles County/University of Southern California Medical Center, Los Angeles. Dr. Rabens is now in private practice in Encino, Calif.

Arch Dermatol. 1975;111(3):357-361. doi:10.1001/archderm.1975.01630150077009

A patient with extensive disabling dystrophic cutaneous calcification and possible scleroderma was treated with orally administered doses of a diphosphonate known as disodium etidronate. This course of therapy seemed to arrest and partially reverse the progression of the calcifying process. Some deep deposits were then seen to dissipate and be partially reabsorbed, while some small superficial deposits were extruded through the skin surface. New deposition or redeposition of calcific deposits were halted in most areas while the patient was under therapy. Clinically, pain was reduced, recurrent abscess formation ceased, and joint mobility was improved.