[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.163.129.96. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
March 1975

Hypochromic Nevus: The Inheritance Question-Reply

Author Affiliations

San Francisco

Arch Dermatol. 1975;111(3):394. doi:10.1001/archderm.1975.01630150114017
Abstract

To the Editor.—  Dr. Coupe is correct in stating that the patient with unilateral systematized hypochromic nevus that he reported and the cases he reviewed, with the exception noted, were sporadic without a familial tendency.1 My comments, which I did not review before publication, are misleading and were meant to indicate that in our own case familial autosomal dominant inheritance was present.The nomenclature for this condition is confusing. Clinically, the lesions resemble a unilateral form of incontinentia pigmenti achromians (IPA)2; IPA occurs primarily in females, but there are cases in males that have been reported recently in the literature.3,4 A family with IPA in which the inheritance pattern was autosomal dominant in type was reported by Rubin.4In Coupe's patient, melanocytes were not found by histochemical techniques, but since electron microscopy was not done, the absence of melanocytes was not verified. In our case, electron

First Page Preview View Large
First page PDF preview
First page PDF preview
×