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April 1975

Congenital and Genetic Disorders Associated With Malignant and Nonmalignant Tumors

Author Affiliations

Burbank, Calif

Arch Dermatol. 1975;111(4):525-527. doi:10.1001/archderm.1975.01630160115022

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To the Editor.—  Skin disorders that are a part of a genetic disorder may be associated with external and internal tumors. Unfortunately the internal tumors can be missed. For example Cowden Disease with the unfortunate misnomer of multiple hamartoma syndrome may be associated with benign tumors and with malignant tumors of the breast, thyroid, colon and other organs. A hamartoma denotes a benign tumor. A malignant melanoma was found in one new patient without metastases.Several authorities have asked me to have this list reprinted from an article in Williams & Wilkins Birth Defects, National Foundation Series 1974, vol 10 entitled "The Urinary System and Others," not a usual source to find such information (Table).I don't expect that this list will stay current since we are continually finding more genetic disorders, as witnessed by the enlarging sizes of McKusick's books on Mendelian Inheritance. (New volume to be published in 1975).

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