In a double-blind, paired-comparison study of the effectiveness of corticosteroid creams used under occlusion for the treatment of moderate to severe psoriasis, a new drug, halcinonide cream, was superior to betamethasone valerate cream, a steroid widely and effectively used for the treatment of psoriasis. This superiority was demonstrated in patients after both one and two weeks of treatment.
Clark RF, Clement ER. Double-Blind Comparison of Halcinonide and Betamethasone ValerateUse With Occlusive Dressings in Psoriasis Treatment. Arch Dermatol. 1975;111(6):731-733. doi:10.1001/archderm.1975.01630180059005