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June 1975

Sebum: Analysis by Infrared SpectroscopyII. The Suppression of Fatty Acids by Systemically Administered Antibiotics

Author Affiliations

From the Department of Dermatology, University of Miami Medical School, Coral Gables, Fla.

Arch Dermatol. 1975;111(6):734-735. doi:10.1001/archderm.1975.01630180062006

Various tetracyclines and erythromycins have been used rather empirically for the systemic treatment of acne vulgaris for more than a decade. It has been impossible to accurately evaluate clinically the numerous derivatives and to compare their effectiveness with other antibiotics such as clindamycin. As a substitute for this approach, this present study ranks these antibiotics, when given orally, as to their effectiveness in suppressing the fatty acids in sebum in normal volunteers. As a group, the tetracyclines were more effective than the erythromycins in decreasing the fatty acids, but clindamycin was significantly more potent than either.