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To the Editor.—
In a recent article in the Archives on cutaneous pseudolymphoma resulting from antigen injections (110:756,1974), Bernstein et al present data suggesting that hyposensitization injection therapy for house dust, bacteria, pollens, and molds resulted in the formation of lymphoreticular cellular infiltrates at the site of injection.It is most important to know the vehicle in which the antigen suspensions were present. If the injections were in an aqueous solution as opposed to an adjuvant mixture, this kind of reaction would be most unusual.Hyposensitization injections causing granulomatous skin reactions are well recognized. However, most of these reactions are due to the adjuvant in the mixture and not to the antigen per se.Hopefully, this important piece of information will be forthcoming.
Samuelson JS. Cutaneous Pseudolymphoma Resulting From Antigen Injections. Arch Dermatol. 1975;111(7):925. doi:10.1001/archderm.1975.01630190115018