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Article
July 1975

Variegate Porphyria

Author Affiliations

McKeesport, Pa

Arch Dermatol. 1975;111(7):926-927. doi:10.1001/archderm.1975.01630190116021
Abstract

To the Editor.—  The case of a 27-year-old woman with variegate porphyria was presented by Freinkel and Ashman to the Chicago Dermatological Society, March 21, 1973, in the Archives (110:653-654, 1974). The findings are similar to those in a 31-year-old woman whom I have been following up for the past two years. These findings include the following: development of bullae and pigmentation of the dorsa of the hands, particularly after sun exposure; episodes of abdominal distress, the history of which was originally overlooked; quantitative 24-hour urine values in which the values of the coproporphyrins exceeded those of the uroporphyrins; and absence of measurable urinary porphobilinogen. There was no history of intake of drugs or unusual amounts of alcohol. Despite a negative screening test for urinary porphobilinogen, uroporphyrins, and coproporphyrins, a quantitative 24-hour urinary porphyrin study was done because the initial clinical features were so consistent with porphyria cutanea tarda. This

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