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July 1975

Multiple Mucosal Neuroma Syndrome

Author Affiliations


Arch Dermatol. 1975;111(7):931. doi:10.1001/archderm.1975.01630190121031

To the Editor.—  The patient presented by Hurwitz in the transactions of the New England Dermatological Society1 may represent a case of the multiple mucosal neuroma syndrome (MMNS). Froboese2 first described this syndrome of multiple neuromas of the tongue, lips, and eyelids, associated with medullary carcinoma of the thyroid and pheochromocytoma. Gorlin et al3 later reviewed it. Sipple4 discussed the association between pheochromocytoma and thyroid carcinoma; he made no mention of mucosal lesions. Bolande5 distinguished between MMNS and Sipple syndrome, but grouped them together as possible neural crest disorders. Finally, the picture labeled "characteristic facies" is identical to those seen in MMNS patients.

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