The sequential application of tretinoin and a corticosteroid ointment was considerably more effective in the treatment of plaque-type psoriasis than either drug alone in a pilot study.
The best results were obtained with 0.3% tretinoin followed by a potent corticosteroid ointment. Combined therapy was particularly efficacious in steroid-resistant psoriasis, including that on the palms, elbows, and knees.
Irritancy from the high-strength tretinoin was a potentially troublesome sideeffect. Care must be taken to avoid drug contact on areas that are easily irritated.
Kaidbey KH, Petrozzi JW, Kligman AM. Treatment of Psoriasis With Topically Applied Tretinoin and Steroid Ointment. Arch Dermatol. 1975;111(8):1001-1003. doi:10.1001/archderm.1975.01630200061006