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September 1975

Complement Component Analysis in AngioedemaDiagnostic Value

Author Affiliations

From the Department of Allergy and Immunology (Drs. Brasher and Starr) and the Department of Clinical Pathology, Section on Biochemistry (Drs. Hall and Spiekerman), Scott and White Clinic, Temple, Tex.

Arch Dermatol. 1975;111(9):1140-1142. doi:10.1001/archderm.1975.01630210056003

Complement component analysis is valuable for differentiating the various types of angioedema. Patients with hereditary angioedema have decreased levels of C1 esterase inhibitor and C4 in the presence of normal amounts of C3 and C1q. Acquired C1 esterase inhibitor deficiency secondary to malignant disease is also manifested by depressed C1 esterase inhibitor and C4, but decreased C1q levels distinguish it from hereditary angioedema. Normal values for these complement components are found in persons with allergic angioedema.