A patient with tumor-stage mycosis fungoides and lymph node involvement had sea-blue (ceroid-containing) histiocytes in her bone marrow. Leukopenia, eosinophilia, and a mild type II β-hyperlipoproteinemia were also features. Seablue histiocytes were demonstrated in the skin after the mycosis fungoides infiltrate had cleared with treatment.
There is a possible interrelationship between the sea-blue histiocytes, the abnormal mycosis cells in the skin, and lipid metabolism.
Robinowitz B, Roenigk HH, Smith MM. Sea-Blue Histiocytes in Mycosis Fungoides. Arch Dermatol. 1975;111(9):1165-1167. doi:10.1001/archderm.1975.01630210081009