• Daily application of 1% fluorouracil cream to normal white skin results in definite morphologic alterations of the epidermis. Although clinical changes were not present, electron microscopic examination of the tissue demonstrates changes especially pronounced in the epidermal keratinocytes. These changes consist of cytoplasmic vacuoles, alterations in the mitochondria, Golgi complex, and endoplasmic reticulum, as well as widened extracellular spaces.
(Arch Dermatol 111:1301-1306, 1975)
Zelickson AS, Mottaz J, Weiss LW. Effects of Topical Fluorouracil on Normal Skin. Arch Dermatol. 1975;111(10):1301-1306. doi:10.1001/archderm.1975.01630220065004