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October 1975

Lichen MyxedematosusA Dermal Infiltrative Disorder Responsive to Cyclophosphamide Therapy

Author Affiliations

From the Division of Dermatology, departments of internal medicine (Drs. Howsden and Herndon) and pathology (Dr. Freeman), University of Texas (Southwestern) Medical School, Dallas.

Arch Dermatol. 1975;111(10):1325-1330. doi:10.1001/archderm.1975.01630220089007

• Lichen myxedematosus is an uncommon, chronic, cutaneous disease of mucin deposition that has resisted a variety of therapies. The discovery of a unique, basic, homogeneous globulin in the sera of many of the patients with this disorder raised questions concerning the relationships between lichen myxedematosus, multiple myeloma, and amyloidosis. Our patient, who lacked the abnormal serum globulin, was successfully treated with cyclophosphamide.

(Arch Dermatol 111:1325-1330, 1975)