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October 1975

Treatment of Nocardial Mycetoma With Trimethoprim and Sulfamethoxazole

Author Affiliations

From the Division of Dermatology, Department of Medicine, Bhumibol Adulyadej Hospital, Donmuang, Bangkok, Thailand (Dr. Nitidandhaprabhas) and the Institute of Dermatology, Ministry of Public Health, Bangkok, Thailand (Dr. Sittapairochana).

Arch Dermatol. 1975;111(10):1345-1348. doi:10.1001/archderm.1975.01630220109013

• Two cases of nocardial mycetoma were successfully treated with a mixture of trimethoprin and sulfamethoxazole (Bactrim). The patient in case 1 showed resistance to treatment with antibiotics and sulfamethoxypyridazine, and the causal agent of the disease could not be isolated. In case 2, bone involvement was seen; the causal agent was N asteroides. No adverse effects of the drug occurred in a period of treatment ranging from three to nine months.

(Arch Dermatol 111:1345:1348, 1975)