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Article
November 1975

Quinidine Photosensitivity

Author Affiliations

From the Department of Dermatology, University of Miami School of Medicine, Jackson Memorial Hospital, and the Veterans Administration Hospital, Miami, Fla.

Arch Dermatol. 1975;111(11):1440-1443. doi:10.1001/archderm.1975.01630230042006
Abstract

• Photodermatitis occurring in three patients taking oral quinidine sulfate cleared when the drug was discontinued and recurred when it was readministered. The dermatitis was experimentally reproduced with long-wave ultraviolet light (UV-A, 320-400 nm) in these three patients, who also exhibited a decreased minimal erythema dose (MED) to hot quartz irradiation. Patients taking quinidine who had no dermatitis exhibited normal MEDs and normal response to UV-A. Normal subjects injected intradermally with quinidine and irradiated with UV-A showed no reaction. These observations indicate that the photosensitive dermatitis to quinidine that occurred in the three patients is idiosyncratic and that the UV-A is at least partially responsible for the development of the dermatitis that correlates with the absorption of quinidine in the UV-A range. Quinidine must be considered among the drugs that can produce photosensitive dermatitis.

(Arch Dermatol 111:1440-1443, 1975)

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