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November 1975


Arch Dermatol. 1975;111(11):1526. doi:10.1001/archderm.1975.01630230128024

Chronic Cutaneous Graft-vs-Host Reaction Following Bone Marrow Transplantation. Presented by Richard Masters, MD; Antoinette F. Hood, MD; A. Benedict Cosini, MD.  A 19-year-old man had severe aplastic anemia that was refractory to medical therapy in February 1973. One month later, he received a bone marrow transplantation from his histocompatibility locus A-(HL-A-) identical brother. Between the ninth and the 11th days after the transplantation, a transient erythematous eruption appeared, concurrent with mild diarrhea. The graft was successful, and the patient was discharged from the hospital on a regimen of prednisone and methotrexate. A recurrence of the slightly pruritic, macular, erythematous eruption, with fine scaling, and of the diarrhea precipitated readmission to the hospital in April 1973. A skin biopsy specimen obtained at that time showed changes compatible with graft-vs-host reaction (GVHR). In the hospital, his condition was complicated by persistent skin lesions, severe diarrhea, weight loss, and abnormal liver function. He

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