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December 1975

Allergic Contact Dermatitis Caused by IdoxuridinePatterns of Cross Reactivity With Other Pyrimidine Analogues

Author Affiliations

From the departments of dermatology (Drs. Amon and Hanifin) and obstetrics and gynecology (Dr. Lis), University of Oregon Health Sciences Center, Portland, Ore.

Arch Dermatol. 1975;111(12):1581-1584. doi:10.1001/archderm.1975.01630240037006

Idoxuridine has been used for many years in the treatment of herpex simplex infections of the eye. Use of the drug for herpes simplex infection of the skin is increasing. Ophthalmologists have noted occasional conjunctival and corneal irritant reactions, but no true delayed cutaneous hypersensitivity has been verified. We report four cases of allergic contact dermatitis from idoxuridine, sensitized by both eye and skin applications. Cross reactivity to brominated and chlorinated, but not fluorinated, pyrimidine analogues is noted. Extensive patch testing indicates the general relationship between the structure of pyrimidine compounds and their antigenic cross reactivity.

(Arch Dermatol 111:1581-1584, 1975)