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January 1976

Immediate and Delayed Hypersensitivity in Chronic Dermatophytosis

Author Affiliations


From the Dermatology Service, Department of Medicine, Letterman Army Medical Center (Dr Sorensen), and Letterman Army Institure of Research (Dr Jones), Presidio of San Francisco. Dr Sorensen is now at Silas B. Hays Hospital, Fort Ord, Calif. Dr Jones is now with the University of Michigan, Ann Arbor.

Arch Dermatol. 1976;112(1):40-42. doi:10.1001/archderm.1976.01630250012003

† Delayed hypersensitivity (DH) to seven common antigens was examined in 38 men with chronic dermatophyte infections and in 20 controls. A similar percentage of the infected and the control groups reacted to four antigens. In addition to showing a low frequency of DH to trichophytin, the infected group also showed a significant reduction in their reactions to intradermal mumps skin test antigen and to a Rhus oleoresin patch test. Two members (5%) of the infected group were anergic to all tests. Patients with chronic dermatophytosis appear to have a relatively specific defect in DH to trichophytin, but their cell-mediated responses to other antigens may also be somewhat decreased. The subjects studied did not appear to suffer excessive morbidity from infectious diseases, other than dermatophytosis.

(Arch Dermatol 112:40-42, 1976)