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To the Editor.—
Recently, we saw a young woman with an unusually severe and prolonged reaction to liquid nitrogen therapy for a small wart on her leg. Further investigation disclosed previously undiagnosed cold urticaria. Although this patient had no systemic problems, with the far more vigorous cryosurgical techniques now popular for treatment of neoplasms, the possibility of inducing histamine shock in such a patient should be seriously considered.
Hoke AW. A Chilling Thought. Arch Dermatol. 1976;112(1):122. doi:10.1001/archderm.1976.01630250066027