• Eight patients had pyoderma gangrenosum. They were given a phendimetrazine tartrate derivative, clofazimine (Lamprene [Britain]), which is a chemotherapeutic agent used mainly in certain mycobacterial infections and which also has phagocytosis-enhancing properties. The effect of this drug was remarkably good, with rapid healing of the lesions commencing 3 to 14 days after treatment was started. The mechanism for the effect of clofazimine in pyoderma gangrenosum is not known.
(Arch Dermatol 112:344-349, 1976)
Michaëlsson G, Molin L, Öhman S, Gip L, Lindström B, Skogh M, Trolin I. ClofazimineA New Agent for the Treatment of Pyoderma Gangrenosum. Arch Dermatol. 1976;112(3):344-349. doi:10.1001/archderm.1976.01630270024006