• Mean concentrations of testosterone in sera collected from pubertal boys at the onset of acne were significantly higher than levels from stage-matched control pubertal boys who did not develop acne (P < .0025). This longitudinal study indicated that acne occurred when other androgen-produced pubertal changes began. Androstenedione and dehydroepiandrosterone levels did not differ between the two groups.
(Arch Dermatol 112:482-484, 1976)
Lee PA. Acne and Serum Androgens During Puberty. Arch Dermatol. 1976;112(4):482-484. doi:10.1001/archderm.1976.01630280012003