• A 71-year-old man, who had a history of a previous bullous drug reaction to a sulfonamide, began receiving an ophthalmic preparation that contained sulfacetamide sodium. The patient received only the ophthalmic sulfonamide, and it was used for one day, but he developed Stevens-Johnson syndrome. This is believed to be the first reported case of StevensJohnson syndrome caused by an ophthalmic sulfonamide. The sulfonamides are the best verified drug-trigger for erythema multiforme and Stevens-Johnson syndrome.
(Arch Dermatol 112:513-514, 1976)
Gottschalk HR, Stone OJ. Stevens-Johnson Syndrome From Ophthalmic Sulfonamide. Arch Dermatol. 1976;112(4):513-514. doi:10.1001/archderm.1976.01630280041010