[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.241.199. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
April 1976

Methotrexate Toxicity and Anemia

Author Affiliations

Redwood City, Calif

Arch Dermatol. 1976;112(4):559. doi:10.1001/archderm.1976.01630280077035

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

To the Editor.—  In a recent report by Celle et al (Eur J Cancer 11:317,1975), rats injected with methotrexate and made anemic by bleeding suffered marked liver damage with diffuse fatty metamorphosis, whereas rats that were not bled suffered no liver toxicity from the same dose of methotrexate despite the development of severe damage to the intestinal mucosa. While the metabolism of methotrexate in the rat may or may not be similar to that in man, this observation behooves those of us using methotrexate for treatment of psoriasis to be particularly cautious in administering this drug to patients with anemia. Repeated measurements of red blood cell as well as white blood cell values should be obtained in patients receiving methotrexate.

First Page Preview View Large
First page PDF preview
First page PDF preview
×