• Several cases of isolated C2 deficiency in man have been reported In the medical literature. The earliest cases did not seem to be associated with known diseases or syndromes; more recently, reports of C2 deficiency associated with systemic lupus erythematosus; anaphylactoid purpura, recurrent infections, and dermatomyositis have appeared.
We report here another case of C2 deficiency. The propositus, a 24-year-old woman, had a lupus erythematosus-like rash and a history of arthralgia, as well as a selective deficiency of C2. Studies of hemolytic C2 of the immediate members of her family indicate an autosomal-recessive mode of inheritance. These findings add to the increasing evidence that a C2 deficiency predisposes some persons to serious vascular diseases.
(Arch Dermatol 112:671-674, 1976)
Douglass MC, Lamberg SI, Lorincz AL, Good RA, Day NK. Lupus Erythematosus-like Syndrome With a Familial Deficiency of C2. Arch Dermatol. 1976;112(5):671-674. doi:10.1001/archderm.1976.01630290021004