• It was impossible to replicate solar urticaria lesions by irradiation in the laboratory, until the role of sweating was recognized. We found that the sweat droplet, acting as a lens, serves as a photointensifier. As such, sweat would appear to play a meaningful role in the pathogenesis of cutaneous photosensitivity reactions, as well as be an adjuvant in phototesting.
(Arch Dermatol 112:850-852, 1976)
Shelley WB, Heaton CL. Pathogenesis of Solar UrticariaSweat Droplet in Testing for Photosensitivity. Arch Dermatol. 1976;112(6):850-852. doi:10.1001/archderm.1976.01630300058013