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To the Editor.—
I have seen several women who have developed hyperpigmentation that we suspect is caused by a fungicide, benomyl (Benlate). Dilute amounts of this compound appear to be photosensitizing without irritation, and the new brown pigment lasts about two to six weeks. The pigment develops without preceding irritation, itching, redness, or other clinical evidence of inflammation.It occurred to me that this product might be useful in the treatment of vitiligo and other diseases resulting in hypopigmentation. I do not have the resources or facilities to conduct a trial with this fungicide. However, I would like to bring it to the attention of the readership, so that anyone interested might pursue this further.
Binder R. Hyperpigmentation Caused by a Fungicide. Arch Dermatol. 1976;112(6):880. doi:10.1001/archderm.1976.01630300076018