† A double-blind prospective study was undertaken to compare low-dosage tetracycline hydrochloride and clindamycin hydrate hydrochloride in the treatment of patients with pustular acne. Clinical improvement was noted in 93.7% of those receiving tetracycline and in 92.8% of those receiving clindamycin. Of those patients who were receiving clindamycin, two patients developed diarrhea and one patient developed pseudomembranous colitis. We conclude, therefore, that clindamycin should not be used as a primary drug in the treatment of acne.
(Arch Dermatol 112:974-976, 1976)
Poulos ET, Tedesco FJ. Acne VulgarisDouble-Blind Trial Comparing Tetracycline and Clindamycin. Arch Dermatol. 1976;112(7):974-976. doi:10.1001/archderm.1976.01630310036007