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To the Editor.—
With reference to the letter from Burton Allyn, MD (the Archives 110:810, 1974), I disagree with the treatment schedule for syphilis recommended by the New York City Department of Health Bureau of Venereal Disease Control, who indicate intervals of "three to five days between injections." We have shown that the minimal useful concentration of penicillin (0.03 units) remains in the blood for seven days following the administration of 2,400,000 units of penicillin G benzathine (Prensa Med Argent 59:1872, 1973). These data are supported by the majority of health authorities, and, in the Guide for Diagnosis and Treatment of Sexually Transmissible Diseases, the Secretary of Public Health of the Argentine Republic recommends 2,400,000 units of penicillin G benzathine every seven days in the treatment of primary and secondary syphilis.
Woscoff A. Treatment Schedule for Syphilis. Arch Dermatol. 1976;112(7):1033. doi:10.1001/archderm.1976.01630310079025